The purpose of this study was to determine the effectiveness of cooperative learning model in the type of Numbered Heads Together (NHT) assisted with picture puzzle Media on self-efficacy and student learning outcomes. The research design used was quasi experimental design in the form of nonequivalent control group design. The sample of this study was class XI in SMA Al Islam Wirosari which was taken by non-probability sampling with the number of 77 students. The data were analyzed by using independent sample t-test, based on the result shows that: (1) The student's self-efficacy score obtained t-count (3.890)> (5% = 1.665), then Ho is rejected and Ha Furthermore. The t-test results on students learning outcomes obtained t-count (3,357)> (5% = 1,665 ), then Ho is rejected and Ha is accepted. (2) Based on the results of the N-Gain test the self-efficacy score of the experimental class was 0.3 and included in the middle category, the control class was 0, 1 was included in the low category, while the N-Gain test result of students learning outcomes in the experimental class were 0.506 and it included in the middle category, in the control class of 0, 285, it included in the low category. This study concluded that the Numbered Heads Together (NHT) in cooperative learning model assisted with picture puzzle media is effective in self-efficacy and student learning outcomes in the coordination system material.