This study explores the various expressions of sadness, a fundamental emotion experienced by all humans. Sadness can arise from various life events, including personal problems, disappointments, and life challenges, making it an inseparable part of the human experience. The purpose of this research is to identify verses related to sadness, Ahmad Mustafa al-Maraghi's interpretation in the book Tafsir al-Maraghi, and its relevance to contemporary society. This research adopts a qualitative approach utilizing library research methods to collect data from various sources, including books, scientific articles, and religious texts such as the Quran. The data collection method uses documentation with a descriptive approach and content analysis (tafsir tahlili). This methodology allows for an in-depth exploration of the social and spiritual dimensions of sadness, with a focus on narratives and interpretations that highlight its significance in human life. The results of this study reveal that sadness with term asā, asafā, baṡṡa and ḥuzn appears in QS. Al-Maidah [5:26], QS. Al-Maidah [5:68], QS. Al-A’raf [7:93], QS. Al-A’raf [7:150], QS. At-Taubah [9:92], QS. Yusuf [12:84], QS. Yusuf [12:86], QS. Al-Kahfi [18:6], QS. Al-Ankabut [29:33], QS. Az-Zukhruf [43:55], QS. Al-Hadid [57:23], and can also arise from various life events, including loss, disappointment, and social isolation. This study highlights the story of Prophet Jacob, illustrating how deep sorrow can affect an individual's health, well-being, and the importance of social support during such times. Additionally, this study identifies that the Quran provides guidance for overcoming sorrow through practices such as prayer and remembering God, which can foster resilience and spiritual growth. By examining the interaction between grief and spirituality, this study aims to show that experiencing grief can lead individuals to seek comfort and strength in their faith. It emphasizes that through understanding and embracing grief, individuals can cultivate resilience and a deeper connection with Allah. Ultimately, this research contributes to the broader discourse on emotional health, showing that grief, though challenging, is a vital aspect of the human journey that can drive spiritual development and personal transformation.