This research is based on the interpretation of KH. Husein Muhammad towards surah ar-Rum verse 21. In general some mufassir only interpret the word sakinah, mawaddah, and rahmah. But, KH. Husein Muhammad made this verse in response to the high percentage of early marriage that occurred in Indonesia. The purpose of this research is to provide a new model of interpretation that society in general can take more value from the Qur'an. KH. Husein Muhammad not only interpreting this verse textually but also interpreted it by looking at the social condition of society, especially related to human rights problems in Indonesia, such as the problem of women's discrimination that still occurs in Indonesia. This early marriage became one example of the response of the re-interpretation that claimedKH. Husein Muhammad. This research is qualitative research with a descriptive-analysis method. In doing this research, the data isobtained through theresearch library from the works of KH. Husein Muhammad and direct interview with him. KH. Husein Muhammad is one of the contemporary scholars who interpreted the Quran based on a female perspective. In interpreting surah ar-Rum verse 21 KH. Husein Muhammad did the interpretation and re-interpretation of his initial interpretation that result in the ban on early marriage today, as early marriage created some problems and harms women