The research has been conducted to determine the effectiveness of Problem Based Learning (PBL) model on the science literacy skill of class X students of MA Amtsilati Bangsri Jepara. The population of this study were all students of class X MA Amtsilati Bangsri Jepara which consisted of 6 classes totaling 190 students, the research sample totaled 62 students consist of 32 students in class X-6 as the experimental class and 30 students in class X-4 as the control class. Sampling used cluster random sampling technique and data collection was done by interview method, observation method, questionnaire method, and test method. The data analysis technique was t-test with a significant level of 0.05. Based on the results of the study, the average science literacy skill of the experimental class was 79.32 and the control class was 70,34. The hypothesis test used is the t-test, the results are tobs = 6,21 with ttable = 2,000 and the critical area is db = 60 {t/t -2,000 or t > 2,000}, which means, PBL (Problem Based Learning) model is effective on student’s scientific literacy skills.