In this study, entitled vaccines from the perspective of the Islamic religion, since Covid 19 has spread widely in Indonesia, the spread is increasing almost every day, so the government implements several rules to break the chain of spread of the Covid 19 virus, one of which is the government recommends vaccines. In this case, there are people who support and reject the vaccine for several reasons, the vaccine itself is divided into several, one of which is the Astra zaneca vaccine where many refuse and accept the vaccine. This happened because of several things, one of which was where the Astra Zaneca vaccine contained pork oil so that some refused and some accepted the vaccine. So in this discussion, we will discuss vaccines from the point of view of the Islamic religion, which in this discussion is to find out how the view of vaccines is from the point of view of Islam. In this research method using descriptive qualitative approach. The type of research used in the discussion itself is a case study, the method of data collection is carried out by conducting observation, interviews, and documentation methods. By including primary data and secondary data. There are people who acceptand there are also those who reject the existence of a vaccine, there are several kinds of vaccines, one of which is the Astra Zaneca vaccine. Where people are still confused in responding to the Astra Zaneca vaccine being accepted or rejected because the Astra Zaneca vaccine contains pork enzymes so that people have doubts when they want to do the vaccine. However, the MUI itself has allowed it for the reason that it is faced with very urgent conditions like today. The benefits of self-vaccination are many, one of which can strengthen or strengthen the immune system in the body. Even when people who have been vaccinated are exposed to the Covid 19 virus, the effects of the virus are not too severe, so there is a difference between people who get the vaccine and those who don't.