In everyday life, of course, humans need something called socialization to the people around them, regardless of religion, ethnicity and race. So that it is inevitable that the association will become wider and freer. This has resulted in a shift in religious values that is more dynamic than what happened in the past. In fact, it often happens that interfaith marriages occur as a reality that exists in society which cannot be denied and is still actual to be discussed, giving rise to differences of opinion between the pros and cons. This study attempts to analyze interfaith marriages in the Qur'an according to the interpretation of Qurtubi and Quraish Shihab in surah al-Baqarah verse 221 and al-Ma'idah verse 5. The purpose of this research is to find out the interpretation of Qurtubi and Quraish Shihab in sura al- Baqarah verse 221 and al-Ma'idah verse 5, then want to analyze the similarities and differences in the interpretations of Qurtubi and Quraish Shihab regarding interfaith marriage. The method to be used in this study is the analytical-comparative method with a qualitative approach and descriptive analysis. The results of this study indicate that the interpretation of Qurtubi and Quraish Shihab in surah al-Baqarah verse 221 both prohibits marrying polytheistic women and men. Whereas in Surah Al-Maidah both of them are permissible but have certain conditions. . Because considering that currently there are many Christian and Jewish religions and their books, the authenticity of them cannot be guaranteed until now. The problem is, is there a guarantee that after marriage he will not be influenced by the religion of his wife who is a person of the book, even though with a record before marriage he agreed to it.