This thesis research starts from the facts and realities that are happening in today's society, as well as the lack of respect for different religions. This is whether in the real world or cyberspace, there are still those who curse or disrespect other religions. This study focused on the analysis of Nadirsyah Hosen's interpretation of religious moderation verses in the book Tafsir Al-Qur'an di Medsos and relevance to today's society. This type of research uses library research with a qualitative approach. The main source of data for this study is the book Tafsir Al-Qur’an di Medsos by Nadirsyah Hosen. In data collection, this research used documentation techniques, namely the author will collect several verses of the Qur'an that explain religious moderation. The author's technique for analyzing these data is to use descriptive analysis techniques, which describe religious moderation in general and according to Nadirsyah Hosen. Based on the research that has been done, Nadirsyah Hosen's interpretation of religious moderation resulted in First, not cursing other people's deities. Second, do not force others to convert to Islam. Third, it is not selfish and considers Allah's mercy to only come down on Muslims. Fourth, be fair to anyone. And the relevance of the Interpretation of Religious Moderation Nadirsyah Hosen's views on society's behavior today, is the foundation for building social harmony, preventing conflict, and responding to global challenges. Especially in this modern era, hate speech against certain religious groups can easily be carried out using social media. So that between religions can not respect and appreciate each other. By encouraging mutual respect for different religions, society can form a solid basis for positive and side by side living together.