This study discusses the use of Audio-Lingual Method and Direct Method to teach Vocabulary, a comparative study of the fourth grade of SDI Roudlotul MujahidinPemalang in the academic year of 2019/2020. This study aimed at investigating the effectiveness of using Audio-Lingual Method and Direct Method to teach vocabulary. The method of the research was a quantitative approach and used quasi experimental design with the treatments held in 3 meetings for each experimental 1 class and experimental 2 class. The writer took one class, consisting of the experimental 1 class and the experimental2 class. The writer divided into 2 grops. Group A which consisted of 14 students as the experimental 1 class, and Group B which consisted of 13 students as the experimental 2 class. From the data analysis, it was found that the result of Independent T-test, the mean of Direct Method is 76.38 and for Audio-Lingual Method is 78.07. It can be concluded that T-observed of Audio-Lingual Method is more higher than T-observed of Direct Method. So, the use of Audio-Lingual Method is more effective than Direct Method to teach students’ vocabulary. It means that there is an effectiveness of using Audio-Lingual Method and Direct Method to teach students’ vocabulary.