Understanding and application of language in the daily life is needed to achieve the ideal function of English learning. There was still found Islamic students who could not introduce themselves correctly using basic words of English. By the case, the researcher used Qomik Qur’an Series Juz 7 and 8 supported with scientific Instruction to develop students’ vocabulary.The type of this study was an experimental research in one group pre-test-post-test design. The participants of this research are 30 students of MI NU Miftahul Ma’arif Kaliwungu Kudus. Data Collection Technique: Testing the Students. Statistical Analysis: Test of Normality, N-Gain, and Paired Sample T-Test. The Significance value (Asymp Sig) is 0.508 (0.508 > 0.05) and The Significance value (Asymp Sig) is 0.372 (0.372 > 0.05), then Ho was rejected. It defined that the distribution of the Pre-Test and the Post-Test data were normally distributed. Z count > Z table, namely -4.109 > -1.645 or a sig value of 0.000 <0.05 according to the statistical test that we use, H0 was rejected, so accept H1. There was a significant difference between the Post Test and Pre Test. Those results indicated that the use of Qomik Qur’an Juz 7 and 8 can develop students’ vocabulary quantity.