This study examined the relationships between the variables: (1) Students’ learning interest (X1) and speaking skills (Y), (2) students’ vocabulary mastery (X2) and speaking skills (Y), and (3) students’ learning interest, vocabulary mastery, and speaking skills. This study's methodology was quantitative, and its design was a correlational study. This research conducted in the academic year 2022–2023, and this research population included 108 SMA Negeri 1 Kramat students. By employing a straightforward random sampling procedure, the sample for this research consisted of 20 students as samples of those. These research tools included speaking assessments, learning interest questionnaires, and vocabulary mastery tests for students. To determine the relationship between the variables in this study, simple regression analysis and correlation analysis were performed. The research's findings showed that students' vocabulary mastery and learning interest had a positive and significant impact on their speaking skills, with a multiple correlation coefficient of 0.701 and a sig. value of 0.000 to 0.05. Since the R-Square was 0.491, it also showed that students' vocabulary mastery and learning desire simultaneously had substantial influence on their speaking skill only to the level of 49.1%, with the other 50.9% being unaccounted-for factors. The study's findings highlight the importance of English teachers and students realizing that speaking ability is significantly influenced by students' vocabulary knowledge and learning interests. Therefore, in order to develop strong speaking abilities, students need to increase their vocabulary knowledge and learning interest.