This research is aimed to analyze the psycholinguistic of a dyslexic in the novel My Name is Brain Brian. The objective of this research is to explain the symptoms, the spelling errors of dyslexia, and the teaching approaches for dyslexia. The subject of the research was Brian as a dyslexic character in the novel. The researcher used qualitative content analysis. The collected data were in the form of sentences, clauses, phrases, words and they were classified into some categories. The data were collected by reading the entire story, coding the required data and classified it. In supporting the data, the researcher also used observation in PKBM Talenta, Semarang. The data were analyzed by organizing the data, coding process, using the coding process for identifying the spelling errors by Snowling, Goulandris, and Defty’s theory and Gavin Reid’s theory in understanding the teaching approaches for dyslexia, conveying the findings of the analysis and making the interpretation. The result of this research showed that; 1) the symptoms of dyslexia covered the difficulty in reading, difficulty in spelling, difficulty in memorization, difficulty in direction and inherited dyslexia. Besides, the strength also existed such as good in arts and good comprehension skills. 2) the spelling errors showed that phonetic errors were the most error (50,7%) than semiphonetic errors (41,8%), while the dysphonetic errors were the least among them (7,5%). 3) the teaching approaches also existed such as multisensory, over-learning, structured and sequential.